The adverse reaction profiles for PROTONIX (pantoprazole sodium) For Delayed-Release Oral Suspension and PROTONIX (pantoprazole sodium) Delayed-Release Tablets are similar. Omeprazole also has more drug interactions than pantoprazole. The lists below are incomplete but highlight some interactions to be aware of while taking oral forms of pantoprazole or omeprazole. Mix pantoprazole powder into 1 teaspoonful of applesauce or apple juice. Do not crush or chew the powder granules, and do not mix them into other foods or drinks. After swallowing the mixture, drink some water to wash it down.
- In case of overdosage, treatment should be symptomatic and supportive.
- In adults, symptomatic response to therapy with PROTONIX does not preclude the presence of gastric malignancy.
- Your doctor may recommend a similar medicine called omeprazole instead as there is more safety information available.
- Median serum gastrin levels remained within normal limits during maintenance therapy with PROTONIX Delayed-Release Tablets.
- If you already have this condition, taking pantoprazole could worsen it.
Pantoprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach. Before taking pantoprazole oral tablets, be sure to tell your doctor about all medications you take, including prescription and over-the-counter types. Also describe any vitamins, herbs, or supplements you use.
This protects the lining of the stomach, esophagus, and intestines from the damaging effects of excessive stomach acid. As such, this article will provide an in-depth analysis of omeprazole and pantoprazole, comparing their effectiveness, uses, dosages, side effects, and more. For context, reflux-related conditions may occur in adults and children of all ages, affecting about 20% and 10% of the population, respectively.
Warnings for people with certain health conditions
Pantoprazole may cause mild side effects other than the ones listed above. Do not take Protonix if you are allergic to pantoprazole or any ingredients contained in this drug. Delayed-release tablets are prepared as enteric-coated tablets so that absorption of pantoprazole begins only after the tablet leaves the stomach.
Costs of prescription drugs can vary depending on many factors. These factors include what your insurance plan covers and which pharmacy you use. If you’re interested in using pantoprazole, talk with your doctor. They can tell you if pantoprazole is right for treating your condition.
Pantoprazole does not accumulate, and its pharmacokinetics are unaltered with multiple daily dosing. Following oral or intravenous administration, the serum concentration of pantoprazole declines biexponentially, with a terminal elimination half-life of approximately one hour. Changes in bone parameters were partially reversible following a recovery how alcohol can affect your heart rate the new york times period. PROTONIX was not found to be effective in a multicenter, randomized, double-blind, placebo-controlled, treatment-withdrawal study of 129 pediatric patients 1 through 11 months of age. Patients were enrolled if they had symptomatic GERD based on medical history and had not responded to non-pharmacologic interventions for GERD for two weeks.
Patient Information for Protonix
Pantoprazole is extensively metabolized in the liver through the cytochrome P450 (CYP) system. Pantoprazole metabolism is independent of the route of administration (intravenous or oral). The main metabolic pathway is demethylation, by CYP2C19, with subsequent sulfation; other metabolic pathways include oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activity. Administration of pantoprazole granules, 40 mg, with a high-fat meal delayed median time to peak plasma concentration by 2 hours.
However, weight-normalized clearance values are similar in women and men. The apparent volume of distribution of pantoprazole is approximately 11 to 23.6 L, distributing mainly in extracellular fluid. The serum protein binding of pantoprazole is about 98%, primarily to albumin.
The usual dosage of pantoprazole varies, depending on the reason you’re taking the drug. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use pantoprazole only for the indication prescribed. Taking pantoprazole long-term may cause you to develop stomach growths called fundic gland polyps. Ask your doctor or pharmacist if you have any questions.
Description for Protonix
Your doctor or pharmacist can tell you about any interactions these items may cause with pantoprazole oral tablets. Pantoprazole is used to treat erosive esophagitis (damage to the esophagus from stomach acid caused by gastroesophageal reflux disease, or GERD) in adults and children who are at least 5 years old. A pre-and postnatal development toxicity study in rats with additional endpoints to evaluate the effect on bone development was performed with pantoprazole sodium. On postnatal day (PND 4) through PND 21, the pups were administered oral doses at 5, 15, and 30 mg/kg/day (approximately 1, 2.3, and 3.2 times the exposure (AUC) in humans at a dose of 40 mg).
Patients received PROTONIX daily for four weeks in an open-label phase, then patients were randomized in equal proportion to receive PROTONIX treatment or placebo for the subsequent four weeks in a double-blind manner. Efficacy was assessed by observing the time from randomization to study discontinuation due to symptom worsening during the four-week mixing ativan and alcohol treatment-withdrawal phase. There was no statistically significant difference between PROTONIX and placebo in the rate of discontinuation. Serum chromogranin A (CgA) levels increase secondary to drug-induced decreases in gastric acidity. The increased CgA level may cause false positive results in diagnostic investigations for neuroendocrine tumors.
If you are also taking sucralfate, take pantoprazole at least 30 minutes before sucralfate. You may like to learn how Pantoprazole and omeprazole (Prilosec) compare. The chart below offers a quick overview of the two drugs. To learn more about using pantoprazole for symptoms of anxiety, talk with your doctor. Pantoprazole may not treat your anxiety, but the drug can be used to help manage GERD, which is a possible symptom of anxiety.
You may be more likely to have a broken bone while using pantoprazole long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy, especially if you are an adult over 50. Long-term treatment with pantoprazole may also make it harder for your body to absorb vitamin B-12, resulting in a deficiency of this vitamin. Talk with your doctor if you need long-term pantoprazole treatment and you have concerns about vitamin B-12 deficiency. Pantoprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.
